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Thirty-five patients with nometastatic gestational trophoblastic neoplasms and 3 patients with metastatic gestational trophoblastic neoplasms were treated primarily with methotrexate and citrovorum factor rescue. The antecedent pregnancy was molar in all patients. The known histologic diagnosis in 34 patients was hydatdiform mole and choriocarcinoma in 3. Up to March 1977, the duration of remissions ranged from 1 to 21 months. Complete and sustained remission was achieved in 91% of patients with nonmetastatic disease and in 2 of the 3 patients with metastases, without evidence of marrow or hepatic and with substantially reduced epithelial toxicity. Response to treatment and the number of courses required to achieve remission were determined solely on the basis of the human chorionic gonadotropin response as measured by the beta subunit radioimmunoassay.
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
September 1976,
Obstetrics and gynecology,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
December 1979,
Obstetrics and gynecology,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
May 1985,
American journal of obstetrics and gynecology,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
February 1980,
Cancer,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
November 1989,
Zhonghua fu chan ke za zhi,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
November 1982,
Cancer,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
June 1987,
Tumori,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
June 1975,
The New England journal of medicine,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
May 1981,
La Clinica terapeutica,
D P Goldstein, and
P Saracco, and
R Osathanondh, and
P R Goldstein, and
A R Marean, and
M R Bernstein
June 1990,
Gynecologic oncology,
