BIOMAT Database Logo BIOMAT Database Logo

Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor. 2010

Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Department of Biological Engineering, Inha University, Incheon, South Korea.

A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.

UI MeSH Term Description Entries
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D012097 Repressor Proteins Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release. Repressor Molecules,Transcriptional Silencing Factors,Proteins, Repressor,Silencing Factors, Transcriptional
D005809 Genes, Regulator Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions. Gene, Regulator,Regulator Gene,Regulator Genes,Regulatory Genes,Gene, Regulatory,Genes, Regulatory,Regulatory Gene
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001426 Bacterial Proteins Proteins found in any species of bacterium. Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D013302 Streptomyces A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
D048372 Streptomyces coelicolor A soil-dwelling actinomycete with a complex lifecycle involving mycelial growth and spore formation. It is involved in the production of a number of medically important ANTIBIOTICS. Streptomyces coelicolor A3(2)

Related Publications

Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
A new TetR family transcriptional regulator required for morphogenesis in Streptomyces coelicolor.
January 2008, Journal of bacteriology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator.
December 2010, Applied and environmental microbiology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins.
September 2011, Journal of structural and functional genomics,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Structural and functional analysis of the TetR-family transcriptional regulator SCO0332 from Streptomyces coelicolor.
February 2008, Acta crystallographica. Section D, Biological crystallography,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
SCO3129, a TetR family regulator, is responsible for osmotic stress in Streptomyces coelicolor.
December 2018, Synthetic and systems biotechnology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor.
July 2013, Applied and environmental microbiology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species.
February 2009, Journal of microbiology and biotechnology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor.
March 2011, Applied and environmental microbiology,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
Structural and genomic DNA analysis of the putative TetR transcriptional repressor SCO7518 from Streptomyces coelicolor A3(2).
November 2014, FEBS letters,
Han-Na Lee, and Jianqiang Huang, and Jong-Hyuk Im, and Seon-Hye Kim, and Jun-Hee Noh, and Stanley N Cohen, and Eung-Soo Kim
A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis.
January 2013, PloS one,
Copied contents to your clipboard!