-transparent.png){kind=logo}
The effect of histamine on cyclic AMP was investigated in control and antigen-sensitized guinea pig lungs. Although histamine elevated the cyclic AMP levels in a dose-dependent manner in both groups, the response was consistently smaller in the sensitized lungs. In vivo pretreatment of control guinea pigs with histamine decreased the subsequent effect of exogenous histamine on cyclic AMP. Phosphodiesterase activity was not different in the two groups and it was not affected by histamine. These results indicate that the process of antigen sensitization results in an altered cyclic AMP response to histamine.
Related Publications
A A Mathé, and
R J Sohn, and
L Volicer
August 1980,
European journal of pharmacology,
A A Mathé, and
R J Sohn, and
L Volicer
August 1974,
Research communications in chemical pathology and pharmacology,
A A Mathé, and
R J Sohn, and
L Volicer
May 1973,
Research communications in chemical pathology and pharmacology,
A A Mathé, and
R J Sohn, and
L Volicer
January 1978,
Advances in cyclic nucleotide research,
A A Mathé, and
R J Sohn, and
L Volicer
November 1976,
Cellular immunology,
A A Mathé, and
R J Sohn, and
L Volicer
October 1959,
The Journal of physiology,
A A Mathé, and
R J Sohn, and
L Volicer
January 1973,
Naunyn-Schmiedeberg's archives of pharmacology,
A A Mathé, and
R J Sohn, and
L Volicer
January 1975,
International archives of allergy and applied immunology,
A A Mathé, and
R J Sohn, and
L Volicer
August 1976,
Respiration physiology,
A A Mathé, and
R J Sohn, and
L Volicer
November 1976,
Cellular immunology,
