An intriguing feature of most eukaryotes is that chloroplast (cp) and mitochondrial (mt) genomes are inherited almost exclusively from one parent. Uniparental inheritance of cp/mt genomes was long thought to be a passive outcome, based on the fact that eggs contain multiple numbers of organelles, while male gametes contribute,at best, only a few cp/mtDNA. However, the process is likely to be more dynamic because uniparental inheritance occurs in organisms that produce gametes of identical sizes (isogamous). In Chlamydomonas reinhardtii,the uniparental inheritance of cp/mt genomes is achieved by a series of mating type-controlled events that actively eliminate the mating type minus (mt-) cpDNA.The method by which Chlamydomonas selectively degrades mt- cpDNA has long fascinated researchers, and is the subject of this review.