BIOMAT Database Logo BIOMAT Database Logo

Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period. 2010

K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

OBJECTIVE Subcutaneous adipose tissue grows rapidly during the first months of life. Lipoprotein lipase (LPL) has a quantitatively important function in adipose tissue fat accumulation and insulin-like growth factor-I (IGF-I) is a determinant of neonatal growth. Recent studies showed that LPL mass in non-heparinized serum (LPLm) was an index of LPL-mediated lipolysis of plasma triacylglycerol (TG). The objective was to know the influence of serum LPL and IGF-I on neonatal subcutaneous fat growth, especially on catch-up growth in low birth weight infants. METHODS We included 47 healthy neonates (30 males, 17 females), including 7 small for gestational age. We measured serum LPLm and IGF-I concentrations at birth and 1 month, and analyzed those associations with subcutaneous fat accumulation. RESULTS Serum LPLm and IGF-I concentrations increased markedly during the first month, and positively correlated with the sum of skinfold thicknesses both at birth (r=0.573, P=0.0001; r=0.457, P=0.0035) and at 1 month (r=0.614, P<0.0001; r=0.787, P<0.0001, respectively). In addition, serum LPLm concentrations correlated inversely to very low-density lipoprotein (VLDL)-TG levels (r=-0.692, P<0.0001 at birth; r=-0.429, P=0.0052 at 1 month). Moreover, the birth weight Z-score had an inverse association with the postnatal changes in individual serum LPLm concentrations (r=-0.639, P<0.0001). CONCLUSIONS Both serum LPLm and IGF-I concentrations were the determinants of subcutaneous fat accumulation during the fetal and neonatal periods. During this time, LPL-mediated lipolysis of VLDL-TG may be one of the major mechanisms of rapid growth in subcutaneous fat tissue. Moreover, LPL, as well as IGF-I, may contribute to catch-up growth in smaller neonates.

UI MeSH Term Description Entries
D007230 Infant, Low Birth Weight An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less. Low Birth Weight,Low-Birth-Weight Infant,Birth Weight, Low,Birth Weights, Low,Infant, Low-Birth-Weight,Infants, Low-Birth-Weight,Low Birth Weight Infant,Low Birth Weights,Low-Birth-Weight Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007236 Infant, Small for Gestational Age An infant having a birth weight lower than expected for its gestational age.
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008066 Lipolysis The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues. Lipolyses
D008071 Lipoprotein Lipase An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34. Heparin-Clearing Factor,Lipemia-Clearing Factor,Diacylglycerol Lipase,Diglyceride Lipase,Post-Heparin Lipase,Postheparin Lipase,Postheparin Lipoprotein Lipase,Factor, Heparin-Clearing,Factor, Lipemia-Clearing,Heparin Clearing Factor,Lipase, Diacylglycerol,Lipase, Diglyceride,Lipase, Lipoprotein,Lipase, Post-Heparin,Lipase, Postheparin,Lipase, Postheparin Lipoprotein,Lipemia Clearing Factor,Lipoprotein Lipase, Postheparin,Post Heparin Lipase
D008297 Male Males
D001724 Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms. Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
An association between subcutaneous fat mass accumulation and hypertension.
July 2021, Journal of general and family medicine,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Relationship between preheparin lipoprotein lipase mass concentration in serum and bare metal stent restenosis.
August 2006, Journal of cardiology,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Association between preheparin serum lipoprotein lipase mass and acute myocardial infarction in Japanese men.
January 2002, Journal of atherosclerosis and thrombosis,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Pre-heparin plasma lipoprotein lipase mass: correlation with intra-abdominal visceral fat accumulation.
July 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Association of adiponectin with serum preheparin lipoprotein lipase mass in women independent of fat mass and distribution, insulin resistance, and inflammation.
October 2014, Metabolic syndrome and related disorders,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Association between skeletal muscle mass and serum concentrations of lipoprotein lipase, GPIHBP1, and hepatic triglyceride lipase in young Japanese men.
April 2019, Lipids in health and disease,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Lingual lipase and fat digestion in the neonatal period.
January 1983, Journal of pediatric gastroenterology and nutrition,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Relationships among serum lipoprotein lipase mass, visceral fat, and retinal nerve fiber layer thickness.
November 2015, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Association between Serum Concentration of Carotenoid and Visceral Fat.
March 2021, Nutrients,
K Yoshikawa, and T Okada, and S Munakata, and A Okahashi, and R Yonezawa, and M Makimoto, and S Hosono, and S Takahashi, and H Mugishima, and T Yamamoto
Relationship between two AMI risk factors: low serum lipoprotein lipase mass and hypoadiponectinemia.
January 2011, Journal of atherosclerosis and thrombosis,
Copied contents to your clipboard!