Biomaterial Database

Effect of dietary NaCl on norepinephrine turnover in the Dahl rat. 1991

T A Kotchen, and N G Blehschmidt, and S R Reddy

Department of Medicine, West Virginia University School of Medicine, Morgantown 26506.

To evaluate neural mechanisms in salt-sensitive hypertension, norepinephrine turnover rates were measured in peripheral tissues and selected brain areas of Dahl salt-sensitive and salt-resistant rats receiving either 1% or 7% NaCl diets for 5 weeks. Norepinephrine turnover was determined by measuring tissue norepinephrine in untreated animals or in separate groups killed 2, 4, 6, and 10 hours after alpha-methyl-tyrosine. Plasma volume (radiolabeled albumin) was also measured. Arterial pressure of Dahl S rats receiving 7% NaCl (167 +/- 4 mm Hg) was higher (p less than 0.001) than that of Dahl S rats receiving 1% NaCl (141 +/- 3mm Hg), which was higher (p less than 0.001) than that of Dahl R rats receiving both NaCl intakes. Norepinephrine turnover was increased (p less than 0.01) by 7% NaCl in both heart and brown adipose tissue in Dahl S rats, whereas norepinephrine turnover in Dahl R rats was decreased (p less than 0.01) by the 7% NaCl intake in the heart and kidney. On the high NaCl intake, norepinephrine turnover in heart and adipose tissue was lower (p less than 0.05) in Dahl R rats than in Dahl S rats. In brain stem tissue, with the 1% NaCl diet, norepinephrine turnover was higher (p less than 0.001) in Dahl S rats than in Dahl R rats, and norepinephrine turnover was inhibited (p less than 0.001) by the high NaCl intake in Dahl S rats but not in Dahl R rats. In posterior hypothalamus, norepinephrine turnover was inhibited (p less than 0.01) by the high NaCl intake in Dahl R rats but not in Dahl S rats.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007031	Hypothalamus	Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.	Lamina Terminalis,Preoptico-Hypothalamic Area,Area, Preoptico-Hypothalamic,Areas, Preoptico-Hypothalamic,Preoptico Hypothalamic Area,Preoptico-Hypothalamic Areas
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009638	Norepinephrine	Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.	Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D011922	Rats, Mutant Strains	Rats bearing mutant genes which are phenotypically expressed in the animals.	Mutant Strains Rat,Mutant Strains Rats,Rat, Mutant Strains,Strains Rat, Mutant,Strains Rats, Mutant
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001933	Brain Stem	The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.	Brainstem,Truncus Cerebri,Brain Stems,Brainstems,Cerebri, Truncus,Cerebrus, Truncus,Truncus Cerebrus
D002001	Adipose Tissue, Brown	A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids.	Brown Fat,Hibernating Gland,Brown Adipose Tissue,Fat, Brown,Tissue, Brown Adipose