-transparent.png){kind=logo}
Second-line chemotherapy of advanced colorectal cancer with sequential high-dose methotrexate and 5-fluorouracil. 1991
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
Cattedra di Oncologia Medica, II Facoltà di Medicina, Università di Napoli, Italy.
Twenty-five patients with pretreated advanced colorectal carcinoma were subjected to second-line chemotherapy with sequential high-dose methotrexate and 5-fluorouracil. In 20 evaluable patients 2 (10%) partial responses, 12 (60%) stable disease and 6 (30%) progressions were observed. Partial responses were maintained for 3 and 4 months respectively; stable disease had a median duration of 4 months. The overall median survival after progression was 7 months. From our results sequential high-dose methotrexate and 5-fluorouracil cannot be recommended as second-line chemotherapy in advanced colorectal cancer.
Related Publications
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
January 1982,
Medical and pediatric oncology,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
February 1996,
Journal of chemotherapy (Florence, Italy),
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
August 1985,
Gan no rinsho. Japan journal of cancer clinics,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
December 1984,
Tumori,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
November 1986,
Cancer treatment reports,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
January 1991,
Journal of surgical oncology. Supplement,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
March 1998,
Gan to kagaku ryoho. Cancer & chemotherapy,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
June 1988,
Leber, Magen, Darm,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
June 1987,
American journal of clinical oncology,
G Palmieri, and
C Gridelli, and
G Airoma, and
R Pepe, and
P Incoronato, and
F Caponigro, and
A R Bianco
January 1995,
Oncology,
