We present the clinical, computer tomografic and patological findings of current lesion of the parapharyngial space. METHODS We retrospectivly analised the clinical, cross-sectional imaging files and the patological results for 33 patients explored during January 2006-March 2008 by a medical team at the "Prof. Dr. N. Oblu" Clinical Hospital. RESULTS In our study we didn't find primitive lesions in the parapharyngial space but, we explored 33 lesions extended in the parapharyngial space with origins around the parapharyngial space. The most frequent hystological types of tumor were represented by squamous cell carcinoma of nasopharyngs (n = 22), followed by primitive lesions in to the infratemporal phosa (n = 5). We had also 2 tumoral cases of the parotyd gland, one of the skull base and 3 facial fractures with involvement in to the parapharyngial space. CONCLUSIONS The infiltrations of parapharyngial space by different lesions require Computer tomographic exams for a precise evaluation of the extension of the lesions, evenetual lymph node metastasis, the presence of tumoral recidive and the orientation to a imagistic diagnosis which will be confirmated by a patological exam. The multidisciplinary approach of these lesions will permit a proper terapeutical management to each case.