Biomaterial Database

The influence of leukotriene receptors' antagonists on experimentally induced ulcer in rats. 2008

Magda Cuciureanu, and Irina-Draga Căruntu, and M Kuchar, and M Nechifor

School of Dental Medicine, Department of Pharmacology, "Gr.T. Popa" University of Medicine and Pharmacy Iaşi.

OBJECTIVE Gastric mucosal cells synthesize a large number of eicosanoids (including leukotrienes) which are distinctively involved in ulcerogenesis. This experimental study investigated the effect of 4 leukotriene receptors' antagonists on indomethacin(IND)-induced ulcer in rats. METHODS Animals were divided into six groups (of 8 rats each) which received as follows: group I (control)--saline; group II--IND 20 mg/kg p.o.; group III--montelukast sodium 10 mg/kg p.o. and IND 20 mg/kg p.o.; group IV-- a quinolinic derivative (19363) 20 rM/kg p.o. and IND 20 mg/kg p.o.; group V--a phenethylamido derivative (20599) 20 microM/kg p.o. and IND 20 mg/ kg p.o.; group VI--a resatophenone derivative (19072) 20 microM/kg p.o. and IND 20 mg/kg p.o. Animals were sacrificed eight hours after the last administration. The gastric index (UI), gastric pH and histopathological exam were performed on the removed stomachs. RESULTS UI was 25.8 +/- 6.3 in group II, 10.20 +/- 2.3 in group III (p < 0.05), 21.60 +/- 2.8 in group IV, 13.40 +/- 2.4 in group V (p < 0.05) and 20.80 +/- 3.9 in group VI. pH values were 2.2 +/- 0.3 in group II, 3.4 +/- 0.9 in group III (p < 0.05), 2.6 +/- 0.8 in group IV, 2.9 +/- 0.7 in group V and 2.5 +/- 0.6 in group VI. The histopathological exam revealed: (i) typical lesions for ulcer in groups II, IV and VI, the most severe being in group II; (ii) only superficial non-hemorrhagic erosions in group V; (iii) small erosion areas alternating with large zones of normal mucosa in group III. The obtained data demonstrated different degrees of gastro-protective activity for the studied leukotriene receptor antagonists. CONCLUSIONS Especially montelukast but also phenethylamido derivative (20599) exhibited a partial gastro-protective effect on IND-induced ulcer in rats.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011804	Quinolines
D003521	Cyclopropanes	Three-carbon cycloparaffin cyclopropane (the structural formula (CH2)3) and its derivatives.
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000085	Acetates	Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.	Acetate,Acetic Acid Esters,Acetic Acids,Acids, Acetic,Esters, Acetic Acid
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000897	Anti-Ulcer Agents	Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.	Anti-Ulcer Drugs,Agents, Anti-Ulcer,Anti Ulcer Agents,Anti Ulcer Drugs,Drugs, Anti-Ulcer
D013276	Stomach Ulcer	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	Gastric Ulcer,Gastric Ulcers,Stomach Ulcers,Ulcer, Gastric,Ulcer, Stomach,Ulcers, Gastric,Ulcers, Stomach
D013440	Sulfides	Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.	Sulfide,Thioether,Thioethers,Sulfur Ethers,Ethers, Sulfur
D015289	Leukotrienes	A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.	Leukotriene