False positive complement fixation tests with respiratory virus preparations in bird fanciers with allergic alveolitis. 1977

A J Taylor, and P Taylor, and D H Bryant, and J L Longbottom, and J Pepys

False positive raised complement fixation titres to egg-grown virus preparations were found in six pigeon fanciers suffering from extrinsic allergic alveolitis but not in six similar budgerigar fanciers. The raised titres in the pigeon fanciers fell fourfold over a short interval in the absence of avian exposure and were attributable to antibodies directed against antigens from hen's egg in which the test virus preparations were grown. Such antigens were shown to be present in the virus preparations. In view of the clinical similarities between influenza and acute extrinsic allergic alveolitis, it is essential that a diagnosis of influenza in bird fanciers is not based on either a single raised titre or a fourfold fall in complement fixation titre without appropriate control tests with avian antigens.

UI MeSH Term Description Entries
D009975 Orthomyxoviridae A family of RNA viruses causing INFLUENZA and other respiratory diseases. Orthomyxoviridae includes INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; INFLUENZAVIRUS D; ISAVIRUS; and THOGOTOVIRUS. Influenza Viruses,Myxoviruses,Orthomyxoviruses,Influenza Virus,Myxovirus,Orthomyxovirus
D010222 Parainfluenza Virus 1, Human A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children. Hemadsorption Virus 2,Human parainfluenza virus 1,Para-Influenza Virus Type 1,Parainfluenza Virus Type 1,Para Influenza Virus Type 1
D003168 Complement Fixation Tests Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1. Complement Absorption Test, Conglutinating,Conglutination Reaction,Conglutinating Complement Absorption Test,Complement Fixation Test,Conglutination Reactions,Fixation Test, Complement,Fixation Tests, Complement,Reaction, Conglutination,Reactions, Conglutination,Test, Complement Fixation,Tests, Complement Fixation
D005189 False Positive Reactions Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Positive Reaction,Positive Reaction, False,Positive Reactions, False,Reaction, False Positive,Reactions, False Positive
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000542 Alveolitis, Extrinsic Allergic A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis. Allergic Alveolitis, Extrinsic,Hypersensitivity Pneumonitis,Pneumonitis, Hypersensitivity,Allergic Alveolitides, Extrinsic,Alveolitides, Extrinsic Allergic,Extrinsic Allergic Alveolitides,Extrinsic Allergic Alveolitis,Hypersensitivity Pneumonitides,Pneumonitides, Hypersensitivity
D000956 Antigens, Viral Substances elaborated by viruses that have antigenic activity. Viral Antigen,Viral Antigens,Antigen, Viral
D001716 Bird Fancier's Lung A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings. Avian Hypersensitivity Pneumonitis,Budgerigar Fancier's Lung,Feather Duvet Lung,Hypersensitivity Pneumonitis, Avian,Pigeon Breeder's Lung,Pneumonitis, Hypersensitivity, Avian,Pneumonitis, Avian Hypersensitivity,Avian Hypersensitivity Pneumonitides,Bird Fancier Lung,Bird Fancier's Lungs,Bird Fanciers Lung,Budgerigar Fancier Lung,Budgerigar Fancier's Lungs,Budgerigar Fanciers Lung,Duvet Lung, Feather,Duvet Lungs, Feather,Feather Duvet Lungs,Hypersensitivity Pneumonitides, Avian,Lung, Bird Fancier's,Lung, Budgerigar Fancier's,Lung, Feather Duvet,Lung, Pigeon Breeder's,Lungs, Bird Fancier's,Lungs, Budgerigar Fancier's,Lungs, Feather Duvet,Lungs, Pigeon Breeder's,Pigeon Breeder Lung,Pigeon Breeder's Lungs,Pigeon Breeders Lung,Pneumonitides, Avian Hypersensitivity
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014777 Virus Diseases A general term for diseases caused by viruses. Viral Diseases,Viral Infections,Virus Infections,Disease, Viral,Disease, Virus,Diseases, Viral,Diseases, Virus,Infection, Viral,Infection, Virus,Infections, Viral,Infections, Virus,Viral Disease,Viral Infection,Virus Disease,Virus Infection

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