N-(tert)-butyloxycarbonyl)-beta,beta-cyclopentyl-cysteine (acetamidomethyl)-methyl ester for synthesis of novel peptidomimetic derivatives. 2010

Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara G. d'Annunzio, Via dei Vestini 31, 66100 Chieti, Italy. a.mollica@unich.it

It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimer's disease (AD), prion disease (CJD) and Parkinson's disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic beta,beta-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.

UI MeSH Term Description Entries
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D003517 Cyclopentanes A group of alicyclic hydrocarbons with the general formula R-C5H9. Cyclopentadiene,Cyclopentadienes,Cyclopentene,Cyclopentenes,Cyclopentane
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D005663 Furans Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran. Tetrahydrofurans
D013438 Sulfhydryl Compounds Compounds containing the -SH radical. Mercaptan,Mercapto Compounds,Sulfhydryl Compound,Thiol,Thiols,Mercaptans,Compound, Sulfhydryl,Compounds, Mercapto,Compounds, Sulfhydryl
D013816 Thermodynamics A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed) Thermodynamic
D017670 Sodium Compounds Inorganic compounds that contain sodium as an integral part of the molecule. Compounds, Sodium
D040761 Biomimetic Materials Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems. Bio-Inspired Devices,Bio-Inspired Materials,Bioinspired Devices,Bioinspired Materials,Biomimetic Devices,Biomimicry Devices,Biomimicry Materials,Bio Inspired Devices,Bio Inspired Materials,Bio-Inspired Device,Bio-Inspired Material,Bioinspired Device,Bioinspired Material,Biomimetic Device,Biomimetic Material,Biomimicry Device,Biomimicry Material,Device, Bio-Inspired,Device, Bioinspired,Device, Biomimetic,Device, Biomimicry,Devices, Bio-Inspired,Devices, Bioinspired,Devices, Biomimetic,Devices, Biomimicry,Material, Bio-Inspired,Material, Bioinspired,Material, Biomimetic,Material, Biomimicry,Materials, Bio-Inspired,Materials, Bioinspired,Materials, Biomimetic,Materials, Biomimicry

Related Publications

Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
December 2003, The journal of peptide research : official journal of the American Peptide Society,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
November 1973, Biochimica et biophysica acta,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
May 2000, Acta crystallographica. Section C, Crystal structure communications,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
June 1974, The Journal of organic chemistry,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
May 1981, Journal of medicinal chemistry,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
June 1976, The Journal of organic chemistry,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
December 1984, International journal of peptide and protein research,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
January 1973, Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
July 1972, Journal of the American Chemical Society,
Adriano Mollica, and Federica Feliciani, and Azzurra Stefanucci, and Ivana Cacciatore, and Catia Cornacchia, and Domenica Torino, and Francesco Pinnen
November 1989, Chemical & pharmaceutical bulletin,
Copied contents to your clipboard!