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[Characteristics of antiviral drugs, excluding antiretroviral agents: update 2009]. 2010

Montse Tuset, and Ester López-Suñé, and Carlos Cervera, and Asunción Moreno, and José M Miró
Servicio de Farmacia, Institut d?Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic Universitari, Barcelona, España. mtuset@clinic.ub.es

This article aims to review herpes simplex, herpes zoster and cytomegalovirus and to summarize the main characteristics of the antiviral drugs available to treat those infections. The review of each drug focuses on dosage according to the treatment indication, dose adjustment in patients with impaired renal or hepatic function, the main pharmacokinetic features, and the most significant adverse effects and drug interactions.

UI MeSH Term Description Entries
D006561 Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.) Herpes Simplex Virus Infection
D006562 Herpes Zoster An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed) Shingles,Zona,Zoster
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral

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