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Energy metabolism was studied in rat myocardial mitochondria by estimation of respiratory enzymes activity and content of the Krebs cycle substrates under conditions of acute and chronic intoxication with ethyl alcohol. In the acute intoxication mitochondrial redox enzymes were inhibited (glutamate- and malate dehydrogenases, NADH cytochrome C oxidoreductase and cytochrome C oxidase), succinate- and lactate dehydrogenases were activated; at the same time, contents of pyruvate, succinate, and alpha-ketoglutarate were elevated and the content of oxalacetic acid was decreased. Prolonged administration of alcohol (within 2 months) caused an intensification of glycolysis and an increase in NADH cytochrome C oxidoreductase pathway with preferable oxidation of succinate and activation of cytochrome C oxidase; the phenomenon appears to be an adaptation to chronic "alcohol hypoxia". Discontinuation of alcohol administration led to deficiency of native substrates in myocardium (primarily, oxalacetic and succinic acids) due to decrease in NAD reduction via alcohol dehydrogenase reaction and to increase in oxidation of NAD-dependent endogenous substrates.
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1993,
Voprosy meditsinskoi khimii,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1975,
Sudebno-meditsinskaia ekspertiza,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
November 1970,
Sovetskaia meditsina,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
May 1989,
Kardiologiia,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1967,
Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
September 1968,
Klinicheskaia meditsina,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1982,
Arkhiv patologii,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
December 1968,
Japanese circulation journal,
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1984,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
V I Shishov, and
N G Novoselova, and
E I Maevskiĭ, and
N A Glotov
January 1963,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
