Detection of retinal nerve fiber layer defects on retinal fundus images for early diagnosis of glaucoma. 2010

Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
Gifu University, Graduate School of Medicine, Department of Intelligent Image Information, 1-1 Yanagido, Gifu, Japan. chisa@fjt.info.gifu-u.ac.jp

Retinal nerve fiber layer defect (NFLD) is a major sign of glaucoma, which is the second leading cause of blindness in the world. Early detection of NFLDs is critical for improved prognosis of this progressive, blinding disease. We have investigated a computerized scheme for detection of NFLDs on retinal fundus images. In this study, 162 images, including 81 images with 99 NFLDs, were used. After major blood vessels were removed, the images were transformed so that the curved paths of retinal nerves become approximately straight on the basis of ellipses, and the Gabor filters were applied for enhancement of NFLDs. Bandlike regions darker than the surrounding pixels were detected as candidates of NFLDs. For each candidate, image features were determined and the likelihood of a true NFLD was determined by using the linear discriminant analysis and an artificial neural network (ANN). The sensitivity for detecting the NFLDs was 91% at 1.0 false positive per image by using the ANN. The proposed computerized system for the detection of NFLDs can be useful to physicians in the diagnosis of glaucoma in a mass screening.

UI MeSH Term Description Entries
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D005189 False Positive Reactions Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Positive Reaction,Positive Reaction, False,Positive Reactions, False,Reaction, False Positive,Reactions, False Positive
D005654 Fundus Oculi The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed) Fundus of the Eye,Ocular Fundus,Fundus, Ocular
D005901 Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed) Glaucomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012372 ROC Curve A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli. ROC Analysis,Receiver Operating Characteristic,Analysis, ROC,Analyses, ROC,Characteristic, Receiver Operating,Characteristics, Receiver Operating,Curve, ROC,Curves, ROC,ROC Analyses,ROC Curves,Receiver Operating Characteristics
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D012815 Signal Processing, Computer-Assisted Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity. Digital Signal Processing,Signal Interpretation, Computer-Assisted,Signal Processing, Digital,Computer-Assisted Signal Interpretation,Computer-Assisted Signal Interpretations,Computer-Assisted Signal Processing,Interpretation, Computer-Assisted Signal,Interpretations, Computer-Assisted Signal,Signal Interpretation, Computer Assisted,Signal Interpretations, Computer-Assisted,Signal Processing, Computer Assisted
D016002 Discriminant Analysis A statistical analytic technique used with discrete dependent variables, concerned with separating sets of observed values and allocating new values. It is sometimes used instead of regression analysis. Analyses, Discriminant,Analysis, Discriminant,Discriminant Analyses

Related Publications

Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
January 2014, Journal of glaucoma,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
January 2020, Advances in experimental medicine and biology,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
June 2018, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
January 2008, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
September 2012, Investigative ophthalmology & visual science,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
September 2022, Ophthalmology science,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
April 1986, Nippon Ganka Gakkai zasshi,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
April 2015, Optometry and vision science : official publication of the American Academy of Optometry,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
January 1992, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
Chisako Muramatsu, and Yoshinori Hayashi, and Akira Sawada, and Yuji Hatanaka, and Takeshi Hara, and Tetsuya Yamamoto, and Hiroshi Fujita
May 2015, Investigative ophthalmology & visual science,
Copied contents to your clipboard!