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Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries span at least 60 kilobases, consist of 15 exons, and exhibit identical exon-intron organization. Exon 12 codes for the covalent FAD-binding-site and is the most conserved exon; the MAOA and MAOB exon 12 products share 93.9% peptide identity. These results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products.
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
January 1989,
Molecular microbiology,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
January 1993,
Immunogenetics,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
July 2001,
Immunogenetics,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
December 1989,
Journal of molecular biology,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
March 1988,
Proceedings of the National Academy of Sciences of the United States of America,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
April 1988,
Science (New York, N.Y.),
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
October 2000,
Biochimica et biophysica acta,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
October 1997,
Genomics,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
February 2000,
Gene,
J Grimsby, and
K Chen, and
L J Wang, and
N C Lan, and
J C Shih
October 1992,
DNA and cell biology,
