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Booster vaccination after neonatal priming with acellular pertussis vaccine. 2010
Markus Knuf, and
Heinz-Josef Schmitt, and
Jeanne-Marie Jacquet, and
Alix Collard, and
Dorothee Kieninger, and
Claudius U Meyer, and
Claire-Anne Siegrist, and
Fred Zepp
Department of Pediatrics, Johannes Gutenberg-University, Mainz, Germany. knuf@kinder.klinik.uni-mainz.de
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
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