Elevated soluble interleukin-2 receptor levels early after heart transplantation and long-term survival and development of coronary arteriopathy. 1991

J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
Multi-Organ Transplant Center, Methodist Hospital, Houston, Texas.

Rejection dynamics after heart transplantation might be characterized by soluble interleukin-2 receptor levels. To determine whether elevated levels early (measured by enzyme-linked immunosorbent assay once weekly the first 3 weeks at time of heart biopsy) after transplantation predict mortality and development of coronary disease, the means of these three determinations and the endomyocardial biopsy scores (McAllister scale 0-10) were compared for survivors and nonsurvivors and patients who had coronary arteriopathy develop and those who did not. Fifty-five patients alive 30 days after heart transplantation were prospectively followed up. Overall, 47 patients were male (85%), and the median age was 51 years. Mean +/- SD follow-up was 26 +/- 15 months (range, 1 to 54 months). There were 38 survivors (69%), and coronary arteriopathy developed in 15 patients (27%). Whereas mean +/- SD heart biopsy scores for the early weeks were similar between survivors and nonsurvivors (3.6 +/- 1.4 vs 4.4 +/- 1.6; p greater than 0.05), the difference in soluble interleukin-2 receptor levels was significant (703 +/- 362 U/ml vs 1793 +/- 1070 U/ml; p less than 0.001). A mean level less than 1000 U/ml in any given patient predicted long-term survival with a 76% sensitivity, 79% specificity, and 88% negative predictive value. Mean receptor levels for those patients in whom coronary arteriopathy did not develop were 880 +/- 846 U/ml and for those with this difficulty, 1410 +/- 590 U/ml (p = 0.001). Late morbidity and mortality after heart transplantation seem predicted by early elevation of plasma soluble interleukin-2 receptor levels.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007165 Immunosuppression Therapy Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. Antirejection Therapy,Immunosuppression,Immunosuppressive Therapy,Anti-Rejection Therapy,Therapy, Anti-Rejection,Therapy, Antirejection,Anti Rejection Therapy,Anti-Rejection Therapies,Antirejection Therapies,Immunosuppression Therapies,Immunosuppressions,Immunosuppressive Therapies,Therapies, Immunosuppression,Therapies, Immunosuppressive,Therapy, Immunosuppression,Therapy, Immunosuppressive
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D003324 Coronary Artery Disease Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. Arteriosclerosis, Coronary,Atherosclerosis, Coronary,Coronary Arteriosclerosis,Coronary Atherosclerosis,Left Main Coronary Artery Disease,Left Main Coronary Disease,Left Main Disease,Arterioscleroses, Coronary,Artery Disease, Coronary,Artery Diseases, Coronary,Atheroscleroses, Coronary,Coronary Arterioscleroses,Coronary Artery Diseases,Coronary Atheroscleroses,Left Main Diseases
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections

Related Publications

J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
January 1992, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
March 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
November 1998, Acta radiologica (Stockholm, Sweden : 1987),
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
September 1989, The American review of respiratory disease,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
March 2001, Clinical cardiology,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
March 1991, Transplantation,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
January 1991, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
February 2001, Pediatrics international : official journal of the Japan Pediatric Society,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
October 1997, Transplantation,
J B Young, and K S Lloyd, and N T Windsor, and B Cocanougher, and D G Weilbaecher, and N S Kleiman, and F W Smart, and D L Nelson, and E C Lawrence
March 1999, European cytokine network,
Copied contents to your clipboard!