Open-close-clench cycles have been studied in 12 children with a lateral forced bite in order to investigate how the neuromuscular system of the mandible adapts itself in the presence of occlusal interferences. The mandibular movements were registered in a frontal plane at the central incisors with an opto-electronic registration technique. Series of 35 cycles were recorded to intercuspal position, against flat occlusal splints constructed in intercuspal raised and retruded positions, and against splints with occlusal stops in a retruded position. Average lateral displacements of the mandible during cycle series against flat occlusal splints were measured relative to cycle series to intercuspal position and relative to series against splints with occlusal stops in the retruded position. The lateral mandibular displacements were registered at maximal tooth-tooth or tooth-splint contact and at 7, 14, and 21 mm mouth-opening. It was found that the mandible in the subjects investigated is displaced to the forced bite side both during cycle series into intercuspal position as well as when occlusal contacts are eliminated by the use of flat occlusal splints.