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Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole. 1991
R J Weikert, and
S Bingham, and
M A Emanuel, and
E B Fraser-Smith, and
D G Loughhead, and
P H Nelson, and
A L Poulton
Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-difluoro and 4-trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.
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