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This investigation confirms that 1alpha-hydroxyvitamin D3 (1alpha-OHD3) is a potent drug for the treatment of patients with pseudo-deficiency rickets (Balsan et al., 1975a; Reade et al., 1975; Prader et al., 1976). 1alpha-OHD3 corrects their intestinal malabsorption of calcium and phosphorus, normalizes their serum calcium and phosphate concentrations and promotes healing of skeletal lesions. This study also shows differences in the needs for 1alpha-OHD3 of children with PDR. Three factors appear to be of importance: familial sensitivity, severity of chronic secondary hyperparathyroidism, and periods of increased growth velocity. Tolerance to long-term 1alpha-OHD3 therapy, at doses varying from 0.5 to 2 microgram/d is excellent. Surveillance of patients should include regular measurements of 24 h urinary excretion of calcium, since hypercalciuria is the first signal of overdosage.
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
March 1998,
The New England journal of medicine,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
July 1981,
The Journal of pediatrics,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
December 1977,
Clinical endocrinology,
S Balsan, and
M Garabedian, and
V Courtecuisse, and
J Guéris, and
J P Dommergues, and
L Creignou, and
M J le Denuff, and
J Rivron
November 1999,
The Journal of clinical endocrinology and metabolism,
