BIOMAT Database Logo BIOMAT Database Logo

Assessment of long term status of sputum positive pulmonary TB patients successfully treated with short course chemotherapy. 2009

V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
Tuberculosis Research Centre, Chennai.

BACKGROUND Long term status of pulmonary tuberculosis (PTB) patients treated with short course chemotherapy (SCC) regimens remains unknown. OBJECTIVE To assess the clinical, bacteriological, radiological status and health related quality of life (HRQoL) of PTB patients 14-18 years after successful treatment with SCC. METHODS In a cross-sectional study, cured PTB patients treated during 1986-1990 at the Tuberculosis Research Centre (TRC) were investigated for their current health status including pulmonary function tests (PFT). The St Georges respiratory questionnaire (SGRQ) was used to assess the HRQoL. RESULTS The mean period after treatment completion for the 363 eligible participants was 16.5 yrs (range 14-18 yrs., 84% coverage); 25 (7%) had been re-treated and 52 (14%) died. Among the investigated, 58 (29%) had persistent respiratory symptoms; 170 (86%) had radiological sequelae but none had active disease. Abnormal PFT was observed in 96 (65%) with predominantly restrictive type of disease in 66 (45%). The SGRQ scores for activity and impact were high implying impairment in HRQoL. CONCLUSIONS Assessment of long term status of cured PTB patients showed an impairment of lung functions and HRQoL highlighting the need to address these issues in the management of TB that may provide added value to patient care.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011788 Quality of Life A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral, social environment as well as health and disease. HRQOL,Health-Related Quality Of Life,Life Quality,Health Related Quality Of Life
D012129 Respiratory Function Tests Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc. Lung Function Tests,Pulmonary Function Tests,Function Test, Pulmonary,Function Tests, Pulmonary,Pulmonary Function Test,Test, Pulmonary Function,Tests, Pulmonary Function,Function Test, Lung,Function Test, Respiratory,Function Tests, Lung,Function Tests, Respiratory,Lung Function Test,Respiratory Function Test,Test, Lung Function,Test, Respiratory Function,Tests, Lung Function,Tests, Respiratory Function
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000995 Antitubercular Agents Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. Anti-Tuberculosis Agent,Anti-Tuberculosis Agents,Anti-Tuberculosis Drug,Anti-Tuberculosis Drugs,Antitubercular Agent,Antitubercular Drug,Tuberculostatic Agent,Tuberculostatic Agents,Antitubercular Drugs,Agent, Anti-Tuberculosis,Agent, Antitubercular,Agent, Tuberculostatic,Anti Tuberculosis Agent,Anti Tuberculosis Agents,Anti Tuberculosis Drug,Anti Tuberculosis Drugs,Drug, Anti-Tuberculosis,Drug, Antitubercular
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D013183 Sputum Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus. Sputum, Induced,Induced Sputum,Induced Sputums,Sputums,Sputums, Induced

Related Publications

V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
Frequency of recurrence among MDR-tB cases 'successfully' treated with standardised short-course chemotherapy.
October 2002, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
Low rate of emergence of drug resistance in sputum positive patients treated with short course chemotherapy.
January 2001, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
[Immunological status of pulmonary tuberculosis patients treated with short term chemotherapy regimen (proceedings)].
June 1979, Bulletin of the International Union against Tuberculosis,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
[Long-term efficacy of full course intermittent short-course chemotherapy on new smear positive tuberculosis patients].
June 1997, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
[Study on pathogenicity of sputum from cavity of sputum negative patients with pulmonary tuberculosis after short course chemotherapy].
September 2000, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
Long term follow up of HIV-infected patients with tuberculosis treated with 6-month intermittent short course chemotherapy.
January 2008, The National medical journal of India,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
[On the types of TB-bacilli-disappearance in sputum of TB patients who are treated with chemotherapy].
July 1961, Iryo,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
Silicotuberculosis: long-term outcome after short-course chemotherapy.
February 1995, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
A comparative study on short course chemotherapy in sputum negative pulmonary tuberculosis.
August 1984, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
V V Banu Rekha, and Rajeswari Ramachandran, and K V Kuppu Rao, and Fathima Rahman, and A R Adhilakshmi, and D Kalaiselvi, and P Murugesan, and V Sundaram, and P R Narayanan
The rates of sputum conversion among new smear positive open pulmonary tuberculosis patients treated under directly observed treatment, short course strategy.
January 2014, Saudi medical journal,
Copied contents to your clipboard!