Evidence for an intensity-coding oscillatory potential in the human electroretinogram. 1991

P Lachapelle
Department of Ophthalmology, McGill University, Montreal Children's Hospital, Quebec, Canada.

Electroretinograms (ERGs) were obtained from normal subjects to various combinations of stimulus and background intensities to examine if, as shown in rabbits, one of the oscillatory potentials (OP2) could be identified as reflecting the absolute intensity of the stimulus (i.e. the intensity irrespective of the state of retinal adaptation). The results presented clearly demonstrate that the peak time and the amplitude of OP2 are highly correlated with the absolute intensity of the stimulus. Linear regression analysis (for light- and dark-adapted data combined) yields a correlation coefficient of r = 0.98 for the peak time of OP2 and r = 0.88 for the amplitude of OP2. The latter equations were obtained from ERGs where the brightest flashes were delivered in light-adaptation and the dimmest in dark-adaptation. This is the first demonstration of a high correlation between the intensity of the stimulus and the amplitude and peak time of a human ERG component which is shown to be linear irrespective of the state of retinal adaptation.

UI MeSH Term Description Entries
D010775 Photic Stimulation Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity. Stimulation, Photic,Visual Stimulation,Photic Stimulations,Stimulation, Visual,Stimulations, Photic,Stimulations, Visual,Visual Stimulations
D010783 Photometry Measurement of the various properties of light. Photometries
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D003623 Dark Adaptation Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation. Scotopic Adaptation,Adaptation, Dark,Adaptation, Scotopic
D004596 Electroretinography Recording of electric potentials in the retina after stimulation by light. Electroretinographies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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