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OBJECTIVE To investigate the clinical characteristics and therapy of laryngeal neuroendocrine carcinoma (LNEC). METHODS Ten cases of LNEC treated in our department were retrospectively analyzed. RESULTS Eight out of 10 cases were were atypical carcinoid: 1 case treated as supraglottic horizontal partial laryngectomy died 22 months after operation; 1 case was lost; the other 6 cases were followed up for more than 2 years. Two cases were small cell type, one received supra-cricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP), neck dissection, and radiotherapy, but died after 14 months; the other was receiving radiotherapy. CONCLUSIONS LNEC is a rare malignant tumor and the diagnosis relies on clinical characteristics, histopathological and immunohistochemistry examination. The different types of LNEC should give different treatment protocols.
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
November 2022,
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
January 2025,
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
January 1995,
Acta otorrinolaringologica espanola,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
July 1990,
Harefuah,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
October 2025,
Ear, nose, & throat journal,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
March 1992,
Archives of pathology & laboratory medicine,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
April 2017,
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
December 2015,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
January 2004,
Revue de laryngologie - otologie - rhinologie,
Cai Li, and
Liang Zhou, and
Yan Shen, and
Li Zhu
September 2014,
Journal of clinical and diagnostic research : JCDR,
