Why are nonlinear fits to data so challenging? 2010

Mark K Transtrum, and Benjamin B Machta, and James P Sethna
Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA. mkt26@cornell.edu

Fitting model parameters to experimental data is a common yet often challenging task, especially if the model contains many parameters. Typically, algorithms get lost in regions of parameter space in which the model is unresponsive to changes in parameters, and one is left to make adjustments by hand. We explain this difficulty by interpreting the fitting process as a generalized interpolation procedure. By considering the manifold of all model predictions in data space, we find that cross sections have a hierarchy of widths and are typically very narrow. Algorithms become stuck as they move near the boundaries. We observe that the model manifold, in addition to being tightly bounded, has low extrinsic curvature, leading to the use of geodesics in the fitting process. We improve the convergence of the Levenberg-Marquardt algorithm by adding geodesic acceleration to the usual step.

UI MeSH Term Description Entries

Related Publications

Mark K Transtrum, and Benjamin B Machta, and James P Sethna
April 2021, BJOG : an international journal of obstetrics and gynaecology,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
August 2017, International journal of radiation oncology, biology, physics,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
May 2009, Journal (Canadian Dental Association),
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
January 2022, Experimental mechanics,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
July 1968, Orvosi hetilap,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
April 2008, The Health service journal,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
September 2012, Biology,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
November 2018, Advances in wound care,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
March 2007, The New York state dental journal,
Mark K Transtrum, and Benjamin B Machta, and James P Sethna
June 2022, Nature reviews. Molecular cell biology,
Copied contents to your clipboard!