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The adenylosuccinate lyase (ADSL) which is essential for generating adenylate, maps to the long arm of chromosome 22. By using a Chinese hamster ovary cell line deficient in ADSL activity, we have constructed a set of 17 somatic cell hybrids containing defined regions of human chromosome 22. This panel was extended with six additional hybrids, obtained in other laboratories using various methods of selection. Southern analysis of the hybrids with 38 chromosome 22 probes defined 14 different subregions which could be linearly organized on the long arm of chromosome 22. The order of the probes thus deduced is fully compatible with their previous localization and with the genetic map. The ADSL gene was further sublocalized between the MB and D22S22. This panel, which enables the rapid assignment of chromosome 22 single copy probes to small subregions, will be an important tool in the construction of a detailed physical map of this part of the genome.
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
February 1993,
American journal of human genetics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
July 1996,
Genomics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
August 1987,
Proceedings of the National Academy of Sciences of the United States of America,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
October 1992,
Genomics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
January 1995,
European journal of human genetics : EJHG,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
January 1981,
Cytogenetics and cell genetics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
April 1995,
Annals of human genetics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
February 1994,
Genomics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
April 1990,
Cancer genetics and cytogenetics,
O Delattre, and
C J Azambuja, and
A Aurias, and
J Zucman, and
M Peter, and
F Zhang, and
M C Hors-Cayla, and
G Rouleau, and
G Thomas
November 1986,
Human genetics,
