Clinical and high resolution computed tomography characteristics of patients with rheumatoid arthritis lung disease. 2009

Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
Medical Department, Hospital Kuala Lumpur, Malaysia. nadiah@gmail.com

BACKGROUND Rheumatoid arthritis (RA) is a systemic disease of unknown cause. A variety of pulmonary disorders have been described in association with RA. Among the most common are interstitial lung disease (ILD) and bronchiectasis. OBJECTIVE This study aims to determine the characteristics of RA patients with lung disease in relation to clinical characteristics, pulmonary function test (PFT) and high resolution computed tomography (HRCT) thorax. METHODS This is a 6-months cross-sectional study involving 63 consecutive RA patients in an outpatient rheumatology clinic. Patients had a mean disease duration of 5 years and above. Disease activity and severity was assessed by Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Rheumatoid Arthritis Articular Damage (RAAD) score. Full pulmonary function test (PFT) and HRCT of thorax were performed. CONCLUSIONS The prevalence of RA-ILD is 44% and 67% of patients are asymptomatic. There was significant higher proportion (68%) in patients of Chinese ethnicity who have ILD. Diffusion capacity of carbon monoxide was abnormal in all patients and forced expiratory flow (FEF)(25-75%) was low in 16%. Restrictive pattern was 66.7% by PFT. The most common HRCT findings were reticulation (46%) followed by ground glass opacities (38.1%) and bronchiectasis (28.6%). There was no association between ILD and male gender, duration of the disease, smoking, rheumatoid factor, extra-articular manifestations, disease activity or severity.

UI MeSH Term Description Entries
D008296 Malaysia A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329) Federation of Malaya,Malay Federation,Malay Peninsula,Malaya,Malaya Federation,Sabah,Sarawak
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D001987 Bronchiectasis Persistent abnormal dilatation of the bronchi. Cylindrical Bronchiectasis,Cystic Bronchiectasis,Saccular Bronchiectasis,Varicose Bronchiectasis,Bronchiectases,Bronchiectasis, Cylindrical,Bronchiectasis, Cystic,Bronchiectasis, Saccular,Bronchiectasis, Varicose,Cylindrical Bronchiectases,Cystic Bronchiectases,Saccular Bronchiectases,Varicose Bronchiectases
D002248 Carbon Monoxide Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed) Monoxide, Carbon
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D004185 Disability Evaluation Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits. Disability Evaluations,Evaluation, Disability,Evaluations, Disability
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup

Related Publications

Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
January 1993, Journal of thoracic imaging,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
February 1994, British journal of rheumatology,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
February 2020, Cureus,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
November 2012, Rheumatology international,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
January 2015, Reumatologia clinica,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
April 1995, Annals of the rheumatic diseases,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
January 2018, Respiratory medicine,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
January 1999, Rheumatology international,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
September 2019, Medicine,
Nadiah Mohd Noor, and Mohamed Said Mohd Shahrir, and Mohd Shahdan Shahid, and Roslina Abdul Manap, and Ahmad Mukari Shahizon Azura, and Shamsul Azhar Shah
April 2020, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
Copied contents to your clipboard!