BIOMAT Database Logo BIOMAT Database Logo

When to screen children with Down syndrome for celiac disease? 2010

Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Department of Pediatrics, General Hospital Subotica, Izvorska 3, 24000 Subotica, Serbia. momodec@tippnet.rs

The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D011503 Transglutaminases Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence. Glutaminyl-Peptide Gamma-Glutamyltransferases,Protein-Glutamine gamma-Glutamyltransferases,Transglutaminase,Gamma-Glutamyltransferases, Glutaminyl-Peptide,Glutaminyl Peptide Gamma Glutamyltransferases,Protein Glutamine gamma Glutamyltransferases,gamma-Glutamyltransferases, Protein-Glutamine
D002446 Celiac Disease A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. Gluten Enteropathy,Sprue, Celiac,Sprue, Nontropical,Celiac Sprue,Gluten-Sensitive Enteropathy,Sprue,Disease, Celiac,Enteropathies, Gluten,Enteropathies, Gluten-Sensitive,Enteropathy, Gluten,Enteropathy, Gluten-Sensitive,Gluten Enteropathies,Gluten Sensitive Enteropathy,Gluten-Sensitive Enteropathies,Nontropical Sprue
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004314 Down Syndrome A chromosome disorder associated either with an extra CHROMOSOME 21 or an effective TRISOMY for chromosome 21. Clinical manifestations include HYPOTONIA, short stature, BRACHYCEPHALY, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, single transverse palmar crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213) Mongolism,Trisomy 21,47,XX,+21,47,XY,+21,Down Syndrome, Partial Trisomy 21,Down's Syndrome,Partial Trisomy 21 Down Syndrome,Trisomy 21, Meiotic Nondisjunction,Trisomy 21, Mitotic Nondisjunction,Trisomy G,Downs Syndrome,Syndrome, Down,Syndrome, Down's
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked

Related Publications

Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Celiac disease in children with Down syndrome.
December 2019, Revista chilena de pediatria,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Accuracy and cost-effectiveness of a new strategy to screen for celiac disease in children with Down syndrome.
December 2000, The Journal of pediatrics,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Time to Screen Children with Celiac Disease for Thyroid Disease?
July 2016, The Journal of pediatrics,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Celiac disease in children and adolescents with Down syndrome.
January 2005, Jornal de pediatria,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Celiac disease in Portuguese children and adults with Down syndrome.
July 2010, European journal of gastroenterology & hepatology,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Celiac disease screening in 100 Turkish children with Down syndrome.
January 2005, The Turkish journal of pediatrics,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Routine Screening for Celiac Disease in Children With Down Syndrome Improves Case Finding.
August 2020, Journal of pediatric gastroenterology and nutrition,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Down syndrome and celiac disease.
November 1995, Journal of pediatric gastroenterology and nutrition,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Celiac disease and Down syndrome.
December 2000, The Journal of pediatrics,
Momcilo Pavlovic, and Nedeljko Radlovic, and Zoran Lekovic, and Zorica Stojsic, and Katja Puleva, and Karolina Berenji
Who to screen and how to screen for celiac disease.
August 2022, World journal of gastroenterology,
Copied contents to your clipboard!