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Livers from male and female BB Wistar spontaneously diabetic rats were perfused in vitro to determine the effects of spontaneously occurring insulin-dependent diabetes on the metabolism of fatty acid. The secretion of triglyceride and the incorporation of [1-14C] oleic acid into perfusate and hepatic triglyceride was reduced by the diabetic state, whereas beta-hydroxybutyrate production and output of total ketone bodies were increased. The spontaneous diabetic Wistar rat clearly is a suitable model to study the derangements induced in lipid/plasma lipoprotein metabolism by the insulin-dependent diabetic state; the data obtained with this model confirm our earlier observations on experimental insulin deficiency induced with alloxan, streptozotocin, and anti-insulin serum.
I Weinstein, and
T B Patel, and
M Heimberg
September 1983,
Veterinary pathology,
I Weinstein, and
T B Patel, and
M Heimberg
June 1993,
Diabetes,
I Weinstein, and
T B Patel, and
M Heimberg
October 1981,
Diabetologia,
I Weinstein, and
T B Patel, and
M Heimberg
July 1986,
Metabolism: clinical and experimental,
I Weinstein, and
T B Patel, and
M Heimberg
February 1981,
Laboratory animal science,
I Weinstein, and
T B Patel, and
M Heimberg
January 1987,
Pancreas,
I Weinstein, and
T B Patel, and
M Heimberg
October 1986,
Mechanisms of ageing and development,
I Weinstein, and
T B Patel, and
M Heimberg
September 1982,
Diabetologia,
I Weinstein, and
T B Patel, and
M Heimberg
January 1987,
Virchows Archiv. A, Pathological anatomy and histopathology,
I Weinstein, and
T B Patel, and
M Heimberg
May 1983,
Metabolism: clinical and experimental,
