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Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)--infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV--SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.
M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
November 1980,
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M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
January 2022,
The American journal of tropical medicine and hygiene,
M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
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M S Hirsch, and
A P Kelly, and
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M S Hirsch, and
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December 1974,
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M S Hirsch, and
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M S Hirsch, and
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D S Chapin, and
T C Fuller, and
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R Kurth
July 1969,
Akusherstvo i ginekologiia,
M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
November 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
August 1978,
Zeitschrift fur Geburtshilfe und Perinatologie,
M S Hirsch, and
A P Kelly, and
D S Chapin, and
T C Fuller, and
P H Black, and
R Kurth
August 1981,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
