A common problem in the management of patients who are undergoing hemodialysis is central venous occlusive disease. There has been extensive literature on the treatment of this important and prevalent problem. Treatment options to date include percutaneous balloon angioplasty, bare metal stents, and surgical bypass. Unfortunately, all the available treatment options have poor long-term patency, requiring repeated interventions. More recently, covered stents have been mentioned in the literature for the treatment of central venous stenosis and obstruction. There are very few data to date on this technology, and further randomized controlled trials will be needed to compare the efficacy of percutaneous balloon angioplasty, bare metal stents, and covered stents. It appears that it is of paramount importance to prevent this difficult problem by limiting access to, or intervention in, the central venous system.