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Liposomal amphotericin B (L-AMB), a lipid-based amphotericin B formulation, has been used in Japan since June 2006 to treat fungal infection. In the 3 years since L-AMB was launched, few reports have been made on its status. To ensure its appropriate use, we restrospectively reviewed its efficacy and safety in treating fungal infections. 25 subjects with fungal infection treated with L-AMB from April 2007 until February 2008. Of those, 16 showed clinical improvement. Elevated serum creatinine occurred in 1 and decreased serum potassium in 6. We found a positive relationship between the serum potassium decrease and L-AMB dose. Logistic regression analysis of this relationship showed that serum potassium tended to fall on day 5 to 6 of L-AMB administration. While L-AMB appears highly effective in fungal infection, it requires serum potassium monitoring to ensure patient safety.
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
May 2019,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
January 2021,
Revista iberoamericana de micologia,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
November 2001,
The Journal of the Association of Physicians of India,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
September 1991,
The Journal of infectious diseases,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
January 1996,
Mycoses,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
January 2013,
Early human development,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
October 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
August 2012,
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
March 2010,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
Yukihiro Hamada, and
Toshiaki Komatsu, and
Yoshinori Seto, and
Hajime Matsubara, and
Hikaru Kume, and
Keisuke Sunakawa, and
Kazuo Yago
January 2005,
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology,
