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Chemotherapy (doxorubicin, cyclophosphamide, and vincristine) was given in a sequential fashion with radiation of the primary tumor and brain to 358 patients with small-cell lung carcinoma (extensive disease in 250, limited in 108). Complete regression of tumor was obtained in 14% of patients with extensive disease and 41% of patients with limited disease, and complete or partial response in 57% and 75%, respectively. Median survival was 26 weeks for patients with extensive disease and 52 weeks for those with limited disease. Response duration was longer for patients in complete remission; one third had disease-free survival greater than 1 year. Toxicity from the combined treatment modalities was no greater than expected from the components given separately: fatal in 3.9%, and life-threatening but reversible in 8.4% of patients. Whole-brain radiation was effective in preventing isolated relapse at that site. This therapy appears both feasible and effective, with acceptable risks and some benefit to most patients.
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
May 1990,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
September 1986,
Seminars in oncology,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
September 1979,
International journal of radiation oncology, biology, physics,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
June 1982,
Cancer,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
June 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
June 1993,
Cancer,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
November 1987,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
December 1980,
Cancer,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
December 1986,
Cancer treatment reports,
R B Livingston, and
T N Moore, and
L Heilbrun, and
R Bottomley, and
D Lehane, and
S E Rivkin, and
T Thigpen
January 1981,
Cancer treatment reports,
