BIOMAT Database Logo BIOMAT Database Logo

Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. 2010

Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Department of Internal Medicine, Section of Endocrinology, Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands. mcmbunck@vumc.nl

OBJECTIVE To study the effect of exenatide on body composition and circulating cardiovascular risk biomarkers. METHODS Metformin-treated patients with type 2 diabetes (N = 69) were randomized to exenatide or insulin glargine and treated for 1 year. Body composition was evaluated by dual-energy X-ray absorptiometry. Additionally, body weight, waist circumference, and cardiovascular biomarkers were measured. RESULTS Treatment with exenatide for 1 year significantly reduced body weight, waist circumference, and total body and trunkal fat mass by 6, 5, 11, and 13%, respectively. In addition, exenatide increased total adiponectin by 12% and reduced high-sensitivity C-reactive protein by 61%. Insulin glargine significantly reduced endothelin-1 by 7%. These changes were statistically independent of the change in total body fat mass and body weight. CONCLUSIONS Exenatide treatment for 1 year reduced body fat mass and improved the profile of circulating biomarkers of cardiovascular risk. No significant changes were seen with insulin glargine except a trend for reduced endothelin-1 levels.

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D001823 Body Composition The relative amounts of various components in the body, such as percentage of body fat. Body Compositions,Composition, Body,Compositions, Body
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Body Composition Indices and Cardiovascular Risk in Type 2 Diabetes. CV Biomarkers are not Related to Body Composition.
January 2020, Open medicine (Warsaw, Poland),
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Hormones, body composition and cardiovascular risk.
January 1993, Basic life sciences,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Hormones, body composition and cardiovascular risk.
March 1995, Asia Pacific journal of clinical nutrition,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Circulating, imaging, and genetic biomarkers in cardiovascular risk prediction.
May 2011, Trends in cardiovascular medicine,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Moderate zinc deficiency negatively affects biomechanical properties of rat tibiae independently of body composition.
December 2007, The Journal of nutritional biochemistry,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease.
January 2021, Frontiers in cardiovascular medicine,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Body composition and cardiovascular risk in hemodialysis patients.
July 2006, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Circulating biomarkers in cardiovascular disease.
January 2009, Disease markers,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Cardiovascular risk at the extremes of body composition.
December 2006, The Journal of pediatrics,
Mathijs C Bunck, and Michaela Diamant, and Bjorn Eliasson, and Anja Cornér, and Rimma M Shaginian, and Robert J Heine, and Marja-Riitta Taskinen, and Hannele Yki-Järvinen, and Ulf Smith
Biomarkers of Body Composition.
February 2024, Seminars in musculoskeletal radiology,
Copied contents to your clipboard!