Biomaterial Database

Understanding and exploiting protein prenyltransferases. 2010

Uyen T T Nguyen, and Roger S Goody, and Kirill Alexandrov

Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065, USA.

UI	MeSH Term	Description	Entries
D004122	Dimethylallyltranstransferase	An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.	Dimethylallyltransferase,Geranylpyrophosphate Synthetase,Prenyltransferase,Dolichyl Phosphate Synthetase,Geranylgeranyl Pyrophosphate Synthetase,Nerylpyrophosphate Synthetase,Synthetase, Geranylpyrophosphate,Synthetase, Nerylpyrophosphate
D013729	Terpenes	A class of compounds composed of repeating 5-carbon units of HEMITERPENES.	Isoprenoid,Terpene,Terpenoid,Isoprenoids,Terpenoids
D017368	Protein Prenylation	A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.	Post-Translational Isoprenylation,Protein Isoprenylation,Protein Farnesylation,Protein Geranylgeranylation,Protein Polyisoprenylation,Farnesylation, Protein,Geranylgeranylation, Protein,Polyisoprenylation, Protein,Prenylation, Protein
D017434	Protein Structure, Tertiary	The level of protein structure in which combinations of secondary protein structures (ALPHA HELICES; BETA SHEETS; loop regions, and AMINO ACID MOTIFS) pack together to form folded shapes. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure.	Tertiary Protein Structure,Protein Structures, Tertiary,Tertiary Protein Structures