Anticancer activity test for extracts of Sarang semut plant (Myrmecodya pendens) to HeLa and MCM-B2 cells. 2010

A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
Research Centre for Biotechnology, Indonesian Institute of Sciences (LIPI), Jalan Raya Bogor Km. 46, Cibinong 16911, Indonesia.

The aim of this study is to investigate anticancer activity of methanol extract (ethylacetate, n-buthanol and water partitions) and water extract from Sarang semut (local name), Myrmecodya pendens which is one of Rubiaceae family. Within Papua area (Indonesia), this medicinal plant has been used traditionally as alternative treatment for ulcer, tumor and cancer. In this study, the extracts of this plant were tested for their activities in some cancer cells (HeLa and MCM-B2 cell). The result showed that water extract of this plant has better anti cancer activity compared to other extracts. The IC50 value of water extract A is 27.61 ppm (HeLa) and 54.57 ppm (MCM-B2), while water extract B is 29.36 ppm (HeLa) and 74.20 ppm (MCM-B2). Our study concluded that polar extract (water) exhibited higher anticancer activity than non-polar extracts (ethylacetate and n-buthanol).

UI MeSH Term Description Entries
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D010946 Plants, Medicinal Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals. Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000972 Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. Antineoplastics, Botanical,Antineoplastics, Phytogenic,Agents, Phytogenic Antineoplastic,Botanical Antineoplastics,Phytogenic Antineoplastic Agents,Phytogenic Antineoplastics
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D019666 Rubiaceae The Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules. Bouvardia,Chiococca,Cruciata,Isertia,Nauclea,Palicourea,Pentanisia,Pentas,Randia,Saprosma,Schumanniophyton,Bouvardias,Chiococcas,Cruciatas,Isertias,Naucleas,Palicoureas,Pentanisias,Randias,Saprosmas,Schumanniophytons

Related Publications

A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
January 1956, Texas reports on biology and medicine,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
August 1976, Cancer treatment reports,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
January 2021, Journal of cancer research and therapeutics,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
January 2016, Journal of B.U.ON. : official journal of the Balkan Union of Oncology,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
May 2024, Saudi journal of biological sciences,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
June 2021, African health sciences,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
January 2016, Journal of B.U.ON. : official journal of the Balkan Union of Oncology,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
February 2017, Scientific reports,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
January 2016, Evidence-based complementary and alternative medicine : eCAM,
A Soeksmanto, and M A Subroto, and H Wijaya, and P Simanjuntak
September 2023, Molecules (Basel, Switzerland),
Copied contents to your clipboard!