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Hyperbaric oxygen therapy (HBOT) at 1, 2, and 2.75 atmospheres absolute (ATA) was used to treat rattlesnake (Crotalus atrox) venom-induced tissue damage and edema in thigh muscles of mice. Tissue damage was evaluated by double-blind histopathologic examination: tissue edema was determined by measuring tissue water content. A total of 10 intermittent exposures to oxygen over a period of 4 days at 2 and 2.75 ATA did not influence the resolution of venom-induced tissue edema, whereas tissue damage was significantly ameliorated as compared to air-treated envenomated controls. HBOT also promoted healing in the venom-injected mice as evidenced by the presence of regenerating muscle cells. It is concluded that HBOT may limit rattlesnake venom-induced myonecrosis and promote healing in a dose-response relationship without reducing venom-induced edema.
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
April 1972,
The American journal of pathology,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
January 1995,
Wiener klinische Wochenschrift,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
January 1982,
Toxicon : official journal of the International Society on Toxinology,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
February 1971,
Toxicology and applied pharmacology,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
October 1973,
Experientia,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
January 1996,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
February 1986,
British journal of experimental pathology,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
January 1982,
Muscle & nerve,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
August 1993,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
J J Kelly, and
K Sadeghani, and
S F Gottlieb, and
C L Ownby, and
K W Van Meter, and
D Torbati
January 1985,
Toxicon : official journal of the International Society on Toxinology,
