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OBJECTIVE To investigate the cell apoptosis and expressions of c-fos and c-jun proteins induced by acrylamide (AA) in L-02 human liver embryo cell. METHODS The cell survival rate, cell apoptosis and protein expressions of c-fos and c-jun were measured respectively after L-02 cell were exposed to different final concentration of AA (low: 0.01, 0.1 mmol/l; middle: 0.1, 0.5, 2.5 mmol/l; high: 5.0, 7.5 mmol/l) for 12 h and 24 h, respectively. RESULTS The cell survival rate in the low dose AA-treated group was higher than that in the control group, but the high dose AA-treated groups demonstrated a significantly lower cell survival rate than the control group (P < 0.05). The percentages of apoptosis were significantly higher than that of the control group in the high dose AA-treated groups (P < 0.05). The expressions of c-fos and c-jun of AA-treated group were higher than that in the control group (P < 0.05), and the expressions increased first and then decreased with the AA exaltation; furthermore, the expressions also raised along with the exprosure time (P < 0.05). CONCLUSIONS AA can induce the apoptosis of L-02 cell and high protein expressions of c-fos and c-jun proto-oncogenes.
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
January 1990,
Annual review of cell biology,
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
May 1994,
Alcohol and alcoholism (Oxford, Oxfordshire),
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
May 2005,
Hepatobiliary & pancreatic diseases international : HBPD INT,
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
August 1996,
Zygote (Cambridge, England),
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
August 1991,
The Journal of investigative dermatology,
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
July 2003,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
January 2003,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
January 1997,
Receptors & signal transduction,
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
July 1996,
British journal of cancer,
Rui Wang, and
Jianjun Liu, and
Cai Huang, and
Qifeng Qian, and
Qing Li, and
Xiaoli Liu
April 1997,
Journal of dental research,
