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Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: a phase II study. 2010
Michele Orditura, and
Gennaro Galizia, and
Vincenzo Napolitano, and
Erika Martinelli, and
Roberto Pacelli, and
Eva Lieto, and
Gaetano Aurilio, and
Loredana Vecchione, and
Floriana Morgillo, and
Giuseppe Catalano, and
Fortunato Ciardiello, and
Alberto Del Genio, and
Natale Di Martino, and
Ferdinando De Vita
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, Second University of Naples, School of Medicine, Naples, Italy.
We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.
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