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Previous research has shown that microinfusion of bombesin into the preoptic area (POA) decreases core body temperature in rats that are food-deprived or made hypoglycemic with insulin. The present study employed 2-deoxy-D-glucose, a competitive inhibitor of glycolysis, to further investigate the importance of a reduction in glucose utilization in the production of bombesin-induced hypothermia. Rats (n = 7) were pretreated with 2-DG (0, 25, 50, 100, 200 mg/kg; IP) followed by bombesin (100 ng/1.0 microliters) microinfusions into the POA. The highest dose of 2-DG (200 mg) was also tested in the absence of bombesin as a control. Pretreatment with 2-DG resulted in a dose-related reduction in Tb following bombesin. Injections of 2-DG alone did not significantly alter Tb. The results provide additional evidence that the production of bombesin-induced hypothermia in fasted rats is linked to a reduction in glucose utilization.
A M Babcock, and
M M Maisel
May 1983,
Life sciences,
A M Babcock, and
M M Maisel
April 1989,
Neuropharmacology,
A M Babcock, and
M M Maisel
December 1981,
Physiology & behavior,
A M Babcock, and
M M Maisel
September 1999,
Neuroreport,
A M Babcock, and
M M Maisel
January 1984,
Acta physiologica Polonica,
A M Babcock, and
M M Maisel
September 1980,
The American journal of physiology,
A M Babcock, and
M M Maisel
September 1989,
British journal of pharmacology,
A M Babcock, and
M M Maisel
May 1980,
Neuropharmacology,
A M Babcock, and
M M Maisel
January 1991,
Advances in experimental medicine and biology,
A M Babcock, and
M M Maisel
August 1990,
Pharmacology, biochemistry, and behavior,
