-transparent.png){kind=logo}
Biotransformation of ent-kaur-16-en-19-oic acid by Psilocybe cubensis. 2010
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
Biotechnology Programme, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Biotranformation of ent-kaur-16-en-19-oic acid (1) using Psilocybe cubensis resulted in hydroxylated products. After two days of incubation, ent-16beta,17-dihydroxy-kauran-19-oic acid (2) was isolated. After further incubation for nine days, two novel metabolites, ent-12alpha,16beta,17-trihydroxy-kauran-19-oic acid (3) and ent-11alpha,16beta,17-trihydroxy-kauran-19-oic acid (4), were obtained. The metabolites were identified by spectroscopic methods and X-ray crystallography. Compounds 1-4 were evaluated for their cytotoxic properties against the human leukaemia K562 cell line; only compound 1 showed moderate activity.
Related Publications
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
October 1999,
Phytochemistry,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
July 2010,
Natural product research,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
June 2020,
Chemistry & biodiversity,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
December 2009,
Phytochemistry,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
June 2002,
Phytotherapy research : PTR,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
June 2003,
Planta medica,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
November 2010,
Head & neck,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
October 2011,
Journal of ethnopharmacology,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
December 2012,
Current drug targets,
Jaraslak Pechwang, and
Prakitsin Sihanonth, and
Surachai Pornpakakul, and
Nongnuj Muangsin, and
Jittra Piapukiew, and
Alisa Vangnai, and
Narongsak Chaichit, and
Siriporn Chuchawankul, and
Amorn Petsom
June 2016,
Biochemical and biophysical research communications,
