-transparent.png){kind=logo}
Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1. 2010
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Synthetic routes have been established for the preparation of regio- and stereoisomerically pure samples of the mono-beta-d-glucuronic acid derivatives of combretastatin A-1, referred to as CA1G1 (5a) and CA1G2 (6a). Judicious choice of protecting groups for the catechol ring was required for the regiospecific introduction of the glucuronic acid moiety. The tosyl group proved advantageous in this regard. The two monoglucuronic acid analogues demonstrate low cytotoxicity (compared to CA1, 2) against selected human cancer cell lines, with CA1G1 being slightly more potent than CA1G2.
Related Publications
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
May 1952,
The Journal of biological chemistry,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
November 2011,
Medicinal chemistry (Shariqah (United Arab Emirates)),
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
May 1993,
Chemical & pharmaceutical bulletin,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
February 2024,
World journal of microbiology & biotechnology,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
January 1953,
Advances in carbohydrate chemistry,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
January 1965,
Chemical & pharmaceutical bulletin,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
June 2002,
Carbohydrate research,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
April 1981,
Steroids,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
May 1997,
The Journal of antibiotics,
Rajendra P Tanpure, and
Tracy E Strecker, and
David J Chaplin, and
Bronwyn G Siim, and
Mary Lynn Trawick, and
Kevin G Pinney
October 2011,
Archiv der Pharmazie,
