Biodistribution of Technetium-99m pertechnetate after total gastrectomy and Roux-en-Y jejunal pouch. 2010

Amália Cínthia Meneses Rêgo, and Arthur Villarim Neto, and Italo Medeiros Azevedo, and Irami Araújo-Filho, and Eryvaldo Sócrates Tabosa Egito, and Aldo Cunha Medeiros
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.

This paper investigates the influence of total gastrectomy, with and without a jejunal pouch, on the biodistribution of the radiopharmaceutical Technetium-99m pertechnetate ((99m)TcO(4)(-)). A quantitative biodistribution study was performed on the 30th postoperative day in Wistar rats, using the Wizard PerkinElmer gamma counter. The percentage of injected radioactivity of (99m)TcO(4)(-) per gram of tissue (% ATI/g) in Roux-en-Y total gastrectomy rats was lower in the lung, brain, and femur, compared to the sham rats (p <.05). In the jejunal pouch rats, the%ATI/g was higher than in the jejunum of sham rats (p <.05). The biodistribution was higher in the lung, brain, and femur of Roux-en-Y pouch rats than in Roux-en-Y rats (p <.05). Serum levels of cobalamin, phosphorus, and calcium were lower in gastrectomized than in sham rats (p <.05). No significant histological change was observed in the jejunum of Roux-en-Y rats. In the jejunal pouch, we found vascular ingurgitation, inflammation, submucosal, and muscular wall hypertrophy and widening of the villi. In conclusion, total gastrectomy in rats affected the biodistribution of (99m)TcO(4)(-) to important organs, mainly when a Roux-en-Y reconstruction without a pouch was performed. Moreover, the operation caused biodistribution-related metabolic changes.

UI MeSH Term Description Entries
D007583 Jejunum The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum. Jejunums
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D005269 Femur The longest and largest bone of the skeleton, it is situated between the hip and the knee. Trochanter,Greater Trochanter,Lesser Trochanter,Femurs,Greater Trochanters,Lesser Trochanters,Trochanter, Greater,Trochanter, Lesser,Trochanters,Trochanters, Greater,Trochanters, Lesser
D005743 Gastrectomy Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed) Gastrectomies
D000713 Anastomosis, Roux-en-Y A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site. Roux-en-Y Anastomosis,Roux-en-Y Diversion,Roux-en-Y Loop,Anastomoses, Roux-en-Y,Anastomosis, Roux en Y,Diversion, Roux-en-Y,Diversions, Roux-en-Y,Loop, Roux-en-Y,Loops, Roux-en-Y,Roux en Y Anastomosis,Roux en Y Diversion,Roux en Y Loop,Roux-en-Y Anastomoses,Roux-en-Y Diversions,Roux-en-Y Loops
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013670 Sodium Pertechnetate Tc 99m A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints. Pertechnetate Sodium,Tc 99m-Pertechnetate,Technetium Tc 99m Pertechnetate,99Tc-Pertechnetate,99TcmO4,99mTcO4,Pertechnetate,Technetium Pertechnetate,Technetium Tc 99m O(4),Technetium-99mTc-pertechnetate,99Tc Pertechnetate,99m-Pertechnetate, Tc,Pertechnetate, Technetium,Sodium, Pertechnetate,Tc 99m Pertechnetate,Technetium 99mTc pertechnetate
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions

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