BIOMAT Database Logo BIOMAT Database Logo

Kinetics and comparative efficacy of ofloxacin versus co-trimoxazole in the asymptomatic bacteriuria of elderly subjects. 1991

H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
1st Department of Propedeutic Medicine, Laiko General Hospital, Athens University School of Medicine, Greece.

In a prospective randomized study ofloxacin (400 mg orally once daily) versus co-trimoxazole (320/1,600 mg orally once daily) were given for 3 weeks in 30 and 22 elderly semimobile patients respectively, suffering from asymptomatic bacteriuria. From the obtained results it was evident that: (a) ofloxacin was superior to co-trimoxazole regarding eradication of bacteriuria (p less than 0.05) particularly in patients with a positive antibody-coated bacteria test; (b) a high rate of superinfections and reinfections with strains resistant to co-trimoxazole was observed in both groups indicative of hidden underlying conditions predisposing to urinary tract infections and (c) ofloxacin did not accumulate in serum during prolonged therapy but the half-life ranged between 8.3 and 10.2 h.

UI MeSH Term Description Entries
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000553 Ambulatory Care Health care services provided to patients on an ambulatory basis, rather than by admission to a hospital or other health care facility. The services may be a part of a hospital, augmenting its inpatient services, or may be provided at a free-standing facility. Outpatient Care,Outpatient Health Services,Clinic Visits,Health Services, Outpatient,Outpatient Services,Services, Outpatient Health,Urgent Care,Care, Ambulatory,Care, Outpatient,Care, Urgent,Cares, Urgent,Clinic Visit,Health Service, Outpatient,Outpatient Health Service,Outpatient Service,Service, Outpatient,Service, Outpatient Health,Services, Outpatient,Urgent Cares,Visit, Clinic,Visits, Clinic
D001437 Bacteriuria The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection. Bacteriurias
D015163 Superinfection A frequent complication of drug therapy for microbial infection. It may result from opportunistic colonization following immunosuppression by the primary pathogen and can be influenced by the time interval between infections, microbial physiology, or host resistance. Experimental challenge and in vitro models are sometimes used in virulence and infectivity studies. Microbial Superinvasion,Superinvasion, Microbial,Microbial Superinvasions,Superinfections,Superinvasions, Microbial

Related Publications

H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
[Ofloxacin versus pipemidic acid and co-trimoxazole].
January 1986, Infection,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Asymptomatic bacteriuria in elderly subjects.
April 1980, Danish medical bulletin,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Ofloxacin versus co-trimoxazole in the treatment of typhoid fever in children.
April 1997, Acta paediatrica Japonica : Overseas edition,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Comparative efficacy of sulphonamide and co-trimoxazole.
September 1973, Lancet (London, England),
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Comparative efficacy of sulphonamide and co-trimoxazole.
September 1973, Lancet (London, England),
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Co-trimoxazole in prevention of bacteriuria after prostatectomy.
August 1976, British medical journal,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Comparison of 2 oral ofloxacin regimens for the treatment of bacteriuria in elderly subjects.
January 1995, Drugs,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
[Asymptomatic bacteriuria in the elderly].
December 1994, Harefuah,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Asymptomatic bacteriuria in the elderly.
December 1987, Infectious disease clinics of North America,
H Giamarellou, and M Iakovou, and M Pistoni, and G Petrikkos, and A Dontas, and P Sfikakis
Asymptomatic bacteriuria in the elderly.
November 1987, The American journal of medicine,
Copied contents to your clipboard!