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The number of PG1(2) receptors in NCB-20 neuronal hybrid cells assayed by specific [(3)H]iloprost binding is substantially reduced when cells are cultured in the presence of tunicamycin, the specific inhibitor of protein N-glycosylation. The effect is reversible, dose and time dependent, and is on the number of receptors not their affinity. Tunicamycin was shown to have a selective effect on glycoprotein synthesis under these conditions with only slight effects on total protein synthesis. These results are consistent with the PG1(2) receptor being a glycoprotein or closely associated with such a glycoprotein whose expression is dependent on N-glycosylation.
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