-transparent.png){kind=logo}
It is known that ozone stress can induce airway hyperresponsiveness (AHR). The underlying cellular and molecular mechanisms are not fully understood. We constructed a successive ozone-stressed rat model and showed that AHR caused by ozone stress presented as increased lung resistance (R(L)) to inhaled histamine but not baseline R(L). Meanwhile, structural disruption and decreased expression of integrin beta4 on airway epithelia were observed. Further regression analysis revealed a significant negative correlation between increases in R(L) to histamine (at 0.32 mg/ml) and mRNA expression of integrin beta4. Moreover, when integrin beta4 on human bronchial epithelial cells was knocked down, we found that reactive oxygen species was increased and apoptosis rates were higher. Overall, this study suggests that downregulation of integrin beta4 is important for the development ozone stress-induced AHR, presumably because it causes increased oxidative damage and epithelial apoptosis.
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
July 1993,
The American review of respiratory disease,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
July 2000,
European journal of pharmacology,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
August 1996,
Environmental toxicology and pharmacology,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
November 1989,
Arerugi = [Allergy],
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
January 1988,
Progress in clinical and biological research,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
September 2016,
The Journal of biological chemistry,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
April 2009,
The Journal of biological chemistry,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
December 2015,
American journal of physiology. Lung cellular and molecular physiology,
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
June 2002,
Research report (Health Effects Institute),
Chi Liu, and
Yang Xiang, and
Hui-jun Liu, and
Ge Gao, and
Susan T Howard, and
Xiao-lin Zhu, and
Xiao-qun Qin
May 1998,
American journal of respiratory and critical care medicine,
