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Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. 2010
Hyota Takamatsu, and
Noriko Takegahara, and
Yukinobu Nakagawa, and
Michio Tomura, and
Masahiko Taniguchi, and
Roland H Friedel, and
Helen Rayburn, and
Marc Tessier-Lavigne, and
Yutaka Yoshida, and
Tatsusada Okuno, and
Masayuki Mizui, and
Sujin Kang, and
Satoshi Nojima, and
Tohru Tsujimura, and
Yuji Nakatsuji, and
Ichiro Katayama, and
Toshihiko Toyofuku, and
Hitoshi Kikutani, and
Atsushi Kumanogoh
Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
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