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The origin of the additional chromosome in 26 trisomy 16 spontaneous abortions was studied using DNA probes for chromosome 16, including a probe for centromeric alpha sequences. We were able to determine the parent and meiotic stage of origin of trisomy in 22 cases, with all being attributable to maternal meiosis I non-disjunction. Furthermore, in each of the remaining four cases the results were compatible with this origin. Thus, it is likely that the high incidence of trisomy 16 results from an abnormal process acting at maternal meiosis I which more frequently involves chromosome 16 than other similar sized chromosomes. In studies of recombination, we found little evidence for an association between reduced or absent recombination and chromosome 16 non-disjunction; however, we were unable to rule out an effect of hyperrecombination.
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
January 1982,
Human genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
October 1980,
Journal of medical genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
January 2010,
Human reproduction (Oxford, England),
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
October 1995,
American journal of human genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
July 1980,
Annals of human genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
November 1977,
Human genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
June 1988,
Human genetics,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
November 1999,
Mutagenesis,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
March 2005,
Congenital anomalies,
T J Hassold, and
D Pettay, and
S B Freeman, and
M Grantham, and
N Takaesu
January 1999,
Annales de genetique,
