Biomaterial Database

Biolistic injection of microparticles with high-power Nd:YAG laser. 2010

Tae-hee Han, and Ardian B Gojani, and Jack J Yoh

School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea.

Irradiation of a high-power laser pulse (above 10(9)W/cm(2)) on thin metal foil causes ablation, which is characterized by a strong plasma-shock formation followed by a rapid expulsion of surface matter. The shock propagates through the foil and reverberates on the rear side causing instant deformation of the metal foil, whose surface is treated with microparticles prior to ablation. Based on this principle of microparticle ejection, we develop a laser-based injector that features controllability and stability. We also perform characterization of the penetration depths at varying confinements and energy levels. The confinement media include glass (BK7), water, and ultrasound gel. Biological tissue was replicated by a gelatin-water solution at a 3% weight ratio. Present data show that the confinement effect results in a significant enhancement of penetration depth reached by 5 microm cobalt microparticles. Also, there exists an optimal thickness at each energy level when using liquid confinement for enhanced particle delivery.

UI	MeSH Term	Description	Entries
D007834	Lasers	An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.	Masers,Continuous Wave Lasers,Pulsed Lasers,Q-Switched Lasers,Continuous Wave Laser,Laser,Laser, Continuous Wave,Laser, Pulsed,Laser, Q-Switched,Lasers, Continuous Wave,Lasers, Pulsed,Lasers, Q-Switched,Maser,Pulsed Laser,Q Switched Lasers,Q-Switched Laser
D008845	Microinjections	The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.	Microinjection
D008863	Microspheres	Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.	Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D004867	Equipment Design	Methods and patterns of fabricating machines and related hardware.	Design, Equipment,Device Design,Medical Device Design,Design, Medical Device,Designs, Medical Device,Device Design, Medical,Device Designs, Medical,Medical Device Designs,Design, Device,Designs, Device,Designs, Equipment,Device Designs,Equipment Designs
D019544	Equipment Failure Analysis	The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.	Materials Failure Analysis,Prosthesis Failure Analysis,Analysis, Equipment Failure,Analysis, Materials Failure,Analysis, Prosthesis Failure,Analyses, Equipment Failure,Analyses, Materials Failure,Analyses, Prosthesis Failure,Equipment Failure Analyses,Failure Analyses, Equipment,Failure Analyses, Materials,Failure Analyses, Prosthesis,Failure Analysis, Equipment,Failure Analysis, Materials,Failure Analysis, Prosthesis,Materials Failure Analyses,Prosthesis Failure Analyses