Epitopes of HLA-A, B, C, DR, DQ, DP and MICA antigens. 2009

Nadim El-Awar, and Paul I Terasaki, and Junchao Cai, and Chun-Tsan Deng, and Mikki Ozawa, and Anh Nguyen, and Mamie Lias, and Nathan Conger
One Lambda Inc., Canoga Park, California, USA.

This chapter presents lists of HLA epitopes that have been defined to date. It also presents examples of reactions of mAb and eluted allosera with the class I, class II and MICAsingle antigen beads. To date, we have identified 110 class I epitopes, of which 47 were defined by mAbs and 63 by alloantibodies that were eluted from rHLA class I single antigen cell lines. We listed 34 epitopes shared by the HLA-A locus antigens, 44 epitopes shared by HLA-B locus antigens, 4 epitopes shared by HLA-C locus antigens, 20 inter-locus epitopes shared by HLA-A-B locus antigens, 5 inter-locus epitopes shared by HLA-B-C locus antigens and 3 inter-locus epitopes shared by HLA-A-B-C locus antigens. Sixty HLA-DR epitopes have been defined mostly by one amino acid (aa) residue on the HLA-DR beta chain. Eighteen HLA-DQ epitopes have been defined on the HLA-DQB chain and on the HLA-DQA chain of the HLA-DQ antigens. A few DQ epitopes were defined by one aa residue. However, most can be defined by several alternative combinations of aa residues. DQA and DP epitopes--few in number at this time--were identified. Only seven MICA epitopes have been defined to date. All epitopes can be defined by an exclusive amino acid.

UI MeSH Term Description Entries
D007518 Isoantibodies Antibodies from an individual that react with ISOANTIGENS of another individual of the same species. Alloantibodies
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D006682 HLA-DP Antigens A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-PL Antigens,HLA-SB Antigens,HLA-DP,HLA-PL,HLA-SB,Antigens, HLA-DP,Antigens, HLA-PL,Antigens, HLA-SB,HLA DP Antigens,HLA PL Antigens,HLA SB Antigens
D006683 HLA-DQ Antigens A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-DC Antigens,HLA-MB Antigens,HLA-DC,HLA-DQ,HLA-DS,HLA-DS Antigens,HLA-LB,HLA-LB Antigens,HLA-MB,Antigens, HLA-DC,Antigens, HLA-DQ,Antigens, HLA-DS,Antigens, HLA-LB,Antigens, HLA-MB,HLA DC Antigens,HLA DQ Antigens,HLA DS Antigens,HLA LB Antigens,HLA MB Antigens
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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