Biomaterial Database

Sympathetic innervation of normal and rheumatoid synovial tissue. 1991

B Widenfalk

Department of Plastic and Hand Surgery, Akademiska Sjukhuset, Uppsala University, Sweden.

Fresh synovial tissue was taken from two normal subjects and five patients with rheumatoid arthritis, and treated so that catecholaminergic sympathetic nerve fibres could be seen. A fluorescent network of varicose fibres was visible in normal as well as in rheumatoid synovial tissue. In the rheumatoid inflammatory tissue an increased number of fluorescent sympathetic nerve fibres could be seen in close proximity to blood vessels, even in the smallest synovial plica, indicating that the proliferation of inflammatory vessels is accompanied by simultaneous sympathetic nerve proliferation. A nervous component might thus contribute to the inflammatory process in human rheumatoid arthritis.

UI	MeSH Term	Description	Entries
D008856	Microscopy, Fluorescence	Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.	Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D001808	Blood Vessels	Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).	Blood Vessel,Vessel, Blood,Vessels, Blood
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000320	Adrenergic Fibers	Nerve fibers liberating catecholamines at a synapse after an impulse.	Sympathetic Fibers,Adrenergic Fiber,Fiber, Adrenergic,Fiber, Sympathetic,Fibers, Adrenergic,Fibers, Sympathetic,Sympathetic Fiber
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D013583	Synovial Membrane	The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.	Synovium,Membrana Synovialis Capsulae Articularis,Membrane, Synovial,Membranes, Synovial,Synovial Membranes